Axon Guidance and Collective Cell Migration by Substrate-Derived Attractants
نویسندگان
چکیده
منابع مشابه
Collective guidance of collective cell migration.
Some cells migrate and find their way as solitary entities. However, during development of multicellular animals and possibly during tumor dissemination, cells often move as groups, associated tightly or loosely. Recent advances in live imaging have aided examination of such 'multicellular cell biology'. Here, I propose a model for how a group of cells can process and react to guidance informat...
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During nervous system development, axons that grow out simultaneously in the same extracellular environment are often sorted to different target destinations. As there is only a restricted set of guidance cues known, regulatory mechanisms are likely to play a crucial role in controlling cell migration and axonal pathfinding. Heparan sulfate proteoglycans (HSPGs) carry long chains of differentia...
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Directed migration of groups of cells is a critical aspect of tissue morphogenesis that ensures proper tissue organization and, consequently, function. Cells moving in groups, unlike single cells, must coordinate their migratory behavior to maintain tissue integrity. During directed migration, cells are guided by a combination of mechanical and chemical cues presented by neighboring cells and t...
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Collective cell migration often involves notable cell-cell and cell-substrate adhesions and highly coordinated motion of touching cells. We focus on the interplay between cell-substrate adhesion and cell-cell adhesion. We show that the loss of cell-surface contact does not significantly alter the dynamic pattern of protrusions and retractions of fast migrating amoeboid cells (Dictyostelium disc...
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ژورنال
عنوان ژورنال: Frontiers in Molecular Neuroscience
سال: 2019
ISSN: 1662-5099
DOI: 10.3389/fnmol.2019.00148